Aquagenic Palmar Wrinkling is a rare, transient disorder induced by brief contact with water. It has been noted in cystic fibrosis patients. We describe a unique case of a 17-year-old male with no history of cystic fibrosis, who presented with shriveled palms and multiple whitish papules following brief water immersion.

Mechanical prosthetic valves, like all foreign bodies, are thrombogenic, requiring anticoagulation to avoid thrombosis and reduce the risk of catastrophic stroke. We reported a case of a 42-year-old female that developed mechanical valve thrombosis and was successfully treated with low infusion thrombolytic therapy using Alteplase (Tpa).