\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[english]{babel}



\usepackage{float}








\begin{document}

\title{COVID-19 restrictions and the incidence and prevalence of prescription
opioid use in Australia -- a nation-wide study}



\author[1]{Monica Jung}%
\author[2]{Dickson Lukose}%
\author[2]{Suzanne Nielsen}%
\author[2]{Simon Bell}%
\author[2]{Geoff Webb}%
\author[2]{Jenni Ilomaki}%
\affil[1]{Monash University Faculty of Medicine Nursing and Health Sciences}%
\affil[2]{Monash University}%


\vspace{-1em}



  
  \date{May 24, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup





\selectlanguage{english}
\begin{abstract}
The COVID-19 pandemic has disrupted seeking and delivery of healthcare.
Different Australian jurisdictions implemented different COVID-19
restrictions. We used Australian national pharmacy dispensing data to
conduct interrupted time series analyses to examine the incidence and
prevalence of opioid dispensing in different jurisdictions. Following
nationwide COVID-19 restrictions, the opioid incidence dropped by -0.40
{[}-0.50, -0.31{]}, -0.33 {[}-0.46, -0.21{]} and -0.21 {[}-0.37,
-0.04{]} /1000 people/week and prevalence dropped by -0.85 {[}-1.39,
-0.31{]}, -0.54 {[}-1.01, -0.07{]} and -0.62 {[}-0.99, -0.25{]} /1000
people/week in Victoria, New South Wales and other jurisdictions,
respectively. Incidence and prevalence increased by 0.29 {[}0.13,
0.44{]} and 0.72 {[}0.11, 1.33{]} /1000 people/week, respectively in
Victoria post-lockdown; no significant changes were observed in other
jurisdictions. No significant changes were observed in the initiation of
long-term opioid use in any jurisdictions. More stringent restrictions
coincided with more pronounced reductions in overall opioid initiation,
but initiation of long-term opioid use did not change.%
\end{abstract}%



\sloppy


\textbf{Hosted file}

\verb`Main text.docx`  available at \url{https://authorea.com/users/493103/articles/575638-covid-19-restrictions-and-the-incidence-and-prevalence-of-prescription-opioid-use-in-australia-a-nation-wide-study}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-1/Figure-1}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-2/Figure-2}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

