Neuroschistosomiasis is a rare entity, it can cause cerebral or spinal cord involvement. high clinical suspicion is needed to diagnose it and rapid treatment is needed to prevent complications.

Guillain-Barré syndrome is an acute immune-mediated demyelinating disease. Typical features include progressive ascending lower extremity weakness and areflexia. Several variants have been described which can make the diagnosis challenging . Here, we report a case of GBS presenting with progressive lower limb weakness and T6 sensory level.