It is comprehended that the systems without any limitation on their Zeno action are enthralled in a vast class of hybrid systems. This article is influenced by a new category of non-autonomous second order measure differential problems with state-dependent delay (SDD) and non-instantaneous impulse (NII). Some new sufficient postulates are created that guarantee solvability and approximate controllability. We employ the fixed point strategy and theory of Lebesgue–Stieltjes integral in the space of piecewise regulated functions. The measure of non-compactness is applied to establish the existence of a solution. Moreover, the measured differential equations generalize the ordinary impulsive differential equations. Thus, our findings are more prevalent than that encountered in the literature. At last, an example is comprised that exhibits the significance of the developed theory.