Neonatal thrombosis, either venous or arterial, are rare complications, however the incidence of thromboembolic events in neonates has increased over the last few decades(1). Critically ill and preterm neonates are at highest risk of such complications. Various Maternal, peri delivery and neonatal risk factors can contribute to development of thrombosis(2). The most common risk factors related to neonate include CVC, umbilical venous catheter and sepsis. Thromboembolic events in neonates can lead to mortality or serious morbidity and disability such as limb loss due to arterial thrombosis, loss of vital vascular access, bleeding risk secondary to anticoagulation therapy, portal hypertension and renal dysfunction(3,4). Standard treatment protocols or guidelines for management are lacking, and whatever available is largely extrapolated from adult data.Here we are going to report two cases, one case of portal vein thrombosis due to sepsis and another case of aortic thrombosis.