Toxic Epidermal Necrolysis (TEN) is potentially life threatening cutaneous disorder usually induced by drugs. Non steroidal anti-inflammatory drugs (NSAIDS) are one of the common groups implicated in drug induced TEN. Aceclofenac is a relatively new NSAID exhibiting preferential cyclooxygenase-2 inhibition. It is widely used in management of musculoskeletal disorders. This report describes TEN induced by aceclofenac in a 58 year old female who self medicated herself with higher dose of aceclofenac for knee joint pain.