Acknowledgments:
This work was supported by NSAF (U2130113), National Natural Science
Foundation of China (81700581); Sichuan Science and Technology Program
(2022JDJQ0065, 2021YFS0387); UESTC-SPPH (ZYGX2021YGLH004).
Abstract :
Cardiac hypertrophy is an adaptive response to increased overload, which
is induced by various physiological or pathological stimuli. It is a
common pathological process of a variety of cardiovascular diseases,
which eventually leads to heart
failure. Several lines of evidence
suggested that autophagy as a double-edged sword was involved in cardiac
hypertrophy. Autophagy, with a typical feature of double-membrane
vesicle called the autophagosome, is a highly conserved lysosomal
degradation process and plays an important role in the regulation of
diverse physiologic and pathologic processes. However, the exact
mechanism underlying the role of autophagy in regulating cardiac
hypertrophy remains largely unknown. Here, we comprehensively
characterize the dual effects of autophagy in promoting or inhibiting
cardiac hypertrophy under different conditions. Moreover, we summarize
the potential therapeutic effects of autophagy modulators on
pathological cardiac hypertrophy. Finally, we discuss the advantages and
challenges of autophagic modulators for the therapy of
pathological cardiac hypertrophy.
Keywords: Autophagy; Cardiac hypertrophy; Autophagy modulator;
Therapeutic target