Oridonin |
Akt-AMPK |
Oridonin expedites autophagic lysosomal
degradation associated with P21 to reduce cardiac hypertrophy and
oxidative injury. |
Oridonin expedites autophagic lysosomal degradation
associated with P21 to reduce cardiac hypertrophy and oxidative injury. |
[79] |
Irisin |
AMPK-ULK1 |
Irisin stimulates autophagic flux to significantly
attenuate cardiac hypertrophy induced by PO via activating AMPK-ULK1
signaling related to mTOR. |
Irisin stimulates autophagic flux to
significantly attenuate cardiac hypertrophy induced by PO via activating
AMPK-ULK1 signaling related to mTOR. |
[80] |
Cucurbitacin B |
Akt |
Cucurbitacin B protects against hypertrophy,
fibrosis and augmented cardiac autophagy to refrain from cardiac
hypertrophy by inhibiting Akt/mTOR/FoxO3a signaling pathway. |
Cucurbitacin B protects against hypertrophy, fibrosis and augmented
cardiac autophagy to refrain from cardiac hypertrophy by inhibiting
Akt/mTOR/FoxO3a signaling pathway. |
[81] |
Aliskiren |
Renin |
Aliskiren inhibits the regulation of Ang
II-PKCβI-ERK1/2 induced by autophagy to attenuate cardiac hypertrophy,
fibrosis and dysfunction under chronic PO stimuli. |
Aliskiren inhibits
the regulation of Ang II-PKCβI-ERK1/2 induced by autophagy to attenuate
cardiac hypertrophy, fibrosis and dysfunction under chronic PO stimuli. |
[82] |
SB-216763 |
GSK-3β |
SB-216763 activates autophagy to protect heart and
renal injury treated by aldosterone. |
SB-216763 activates autophagy to
protect heart and renal injury treated by aldosterone. |
[83] |
Allicin |
mTOR |
Allicin suppresses autophagy to preserve cardiac
hypertrophy through activating PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling
pathways. |
Allicin suppresses autophagy to preserve cardiac hypertrophy
through activating PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways. |
[11] |
Rapamycin |
mTORC1 |
Rapamycin inhibits mTORC1 and increases the level
of autophagy activity to prevent from the development of cardiac
hypertrophy. |
Rapamycin inhibits mTORC1 and increases the level of
autophagy activity to prevent from the development of cardiac
hypertrophy. |
[84, 85] |
Amalaki Rasayana |
Unknown |
Amalaki Rasayana increases autophagy and
significantly decreases left ventricular hypertrophy in male Wistar
rats. |
Amalaki Rasayana increases autophagy and significantly decreases
left ventricular hypertrophy in male Wistar rats. |
[86] |
Curcumin |
AMPK |
Curcumin ameliorated CH and fibrosis in a rat model
induced by isoproterenol via mTOR/autophagy signaling pathway. |
Curcumin ameliorated CH and fibrosis in a rat model induced by
isoproterenol via mTOR/autophagy signaling pathway. |
[87] |
Metformin |
AMPK |
Metformin stimulates autophagy to inhibit hypertrophy
and attenuates cardiac dysfunction via activating of mTORC1. |
Metformin
stimulates autophagy to inhibit hypertrophy and attenuates cardiac
dysfunction via activating of mTORC1. |
[88] |
Corosolic Acid |
AMPK |
Corosolic Acid can prevent cardiac hypertrophy
by regulating AMPK-dependent autophagy. |
Corosolic Acid can prevent
cardiac hypertrophy by regulating AMPK-dependent autophagy. |
[89] |
Simvastatin |
Hydroxymethylg-lutaryl coenzyme A reductase |
Simvastatin
inhibits overactive autophagy and increase the expression of 14-3-3,
thereby protecting the stress-overloaded heart. |
Simvastatin inhibits
overactive autophagy and increase the expression of 14-3-3, thereby
protecting the stress-overloaded heart. |
[90] |
Baicalein |
FOXO3a |
Baicalein increases the expression of catalase and
FUN14 domain containing 1 (FUNDC1) and eliminates ROS and promotes
autophagy to reduce isoproterenol-induced cardiac hypertrophy via
targeting FOXO3a. |
Baicalein increases the expression of catalase and
FUN14 domain containing 1 (FUNDC1) and eliminates ROS and promotes
autophagy to reduce isoproterenol-induced cardiac hypertrophy via
targeting FOXO3a. |
[91] |