Background and Purpose Tibetan medicine is one of the oldest traditional medicine systems in the world. Taking the Ruyi Zhenbao tablet (RYZB) as an example, which is a widely used classic oral Tibetan medicine, this article discusses the pharmacokinetics of single administration and long-term treatment, analyzed its metabolic properties and tissue distribution in vivo. Experimental approach After single administration, blood samples were collected before administration and different time points after administration in different groups of rats. In the study of long-term treatment effects, blood samples were collected from the animals in each group on days 1, 15, 30, and on day 15 after withdrawal. Key Results After a single administration, the dose change had no significant effect on the T1/2 and Tmax of agarotetrol, isoliquiritigenin, and piperine (p > 0.05). There was a certain correlation between the increase in AUC0-t and the Cmax of agarotetrol, isoliquiritigenin, piperine, and the increase in dosage; dose range of 0.225-0.900 g/kg. There were no significant differences in Cmax and AUC0-t of ferulic acid at different doses (p > 0.05). Conclusion and Implications Through the establishment of the previously developed methodology, the pharmacokinetic properties of RYZB were analyzed after single administration and long-term administration. Our findings confirmed this approach for the exploration and establishment of a pharmacokinetic evaluation of Tibetan medicine, to support its guiding role in clinical application, but also to accelerate research into Tibetan medicine theory and medicine and to provide a solid foundation for the translation of Tibetan medicine throughout the world.

A molecular-level Fluid Catalytic Cracking (FCC)-Gasoline Hydrotreating (GH) process coupling model was established based on the Structure Oriented Lumping (SOL) method to guide the precise control of the hydrocarbon compositions in gasoline. 96 FCC reaction rules and 24 GH reaction rules were formulated, and a reaction network containing about 120,000 reactions was constructed. In order to establish the FCC-GH process coupling model, the effective transfer of composition information between the two processes was realized through the molecular composition matrix of gasoline. The molecular composition matrix of gasoline was obtained according to the classification rules of the molecular composition matrix of FCC products. The conversion laws of hydrocarbon molecules in gasoline were investigated by tracking their generation paths and reaction paths. The influences of reaction conditions on the distribution of hydrocarbons in the product gasoline could be calculated quantitatively by the FCC-GH process coupling model at molecular level.