Echocardiography
Offspring echocardiography following ACS exposure was assessed in eight
studies. Five of these studies assessed only the presence or absence of
patent ductus arteriosus (PDA) - three found no difference in offspring
exposed to ACS compared to controls 3530 31, and two found that the
incidence of PDA was reduced in infants who had been exposed to ACS at
specific time points or in subgroup analyses 3637. The remaining three studies assessed cardiac
structure and function using a wide range of echocardiographic
parameters. Two of these studies found no difference between offspring
exposed to ACS and controls 18 24.
One showed transient hypertrophic cardiomyopathy in neonates exposed to
multiple ACS doses when comparing echocardiographic parameters to
population norms 38.