Introduction
Ankylosing spondylitis (AS) is an inflammatory disorder with many unidentified reasons. The primary involvement in AS cases is an axial skeleton, defined by joint deformity, stiffness, enthesitis with pain, and sacroiliac arthritis (1). Systemic inflammation leads to stiffness and pain in the entheses, spine, and sacroiliac joint resulting in spinal curvature loss and movement restriction. Advanced disease is possible to lead to spine and sacroiliac joint fusion, causing a ”bamboo spine” condition. Enthesopathy, including plantar fasciitis and Achilles tendonitis, may happen early stage of the disease and result in structural damage. Peripheral joints, primarily in the lower limbs such as the hip, and knee, can also be affected (2).
Neuropathic pain can be experienced in AS cases, endorsed by abnormalities in the brain’s gray matter and neural correlates. The AS clinical picture includes neuropathic pain, mood deficits, and motor impairment. Hence, back pain in subjects with AS may be related to neuropathic pain (3). Also, in AS cases, no precise data showed Axonal Sensory-Motor Polyneuropathy in these patients. Although, some research found a correlation between AS and peripheral neuropathy (3-5). Thus, this case report revealed an AS subject with polyneuropathy, a rare disease manifestation.