Objective: Analysis of the prevalence and distribution patterns of aeroallergens in Children with respiratory allergic diseases in Sichuan province based on skin prick test (SPT) results. Methods: This retrospective cross-sectional study included 7,880 pediatric patients with atopic diseases in outpatient department of West China Second University Hospital between January 2023 and December 2024. All patients completed standardized SPT. Results: Among the 7,880 pediatric patients, 48.6% showed positive results on SPT, the positive rate of SPT in boys was much higher than in girls ( P < 0.01) .The top three allergens ranked by sensitization rates in (SPT) were as follows: Dermatophagoides pteronyssinus (Der.p), Dermatophagoides farinae ( Der.f), and house dust. Among the 3,826 patients with a positive SPT result, the majority of patients (86.5%) were sensitized to two or more allergens. Most allergens exhibited the highest positive rates in the Sichuan Basin. With increasing age, the positive rates for inhalant allergens showed an upward trend except cat dander and feathers. Across all age groups, the three most frequently detected allergens were Der.f, Der.p, and house dust, also exhibited the highest positive rates among all disease group. Preschool children had the lowest overall positive. Conclusion: Der.p and Der.f are the predominant airborne allergens, followed by house dust, animal dander, and cockroaches. Sensitization rates, number and characteristics to inhalant allergens vary across different genders, age groups, medical conditions, geographic regions, and climates.

Background: Numerous guidelines have been published for atopic dermatitis management in children in recent years. To date, the quality of the newest guidelines has not been appraised. Objective: To identify and evaluate guidelines for the management of atopic dermatitis in children. Design: A review of the guidelines for the management of atopic dermatitis in children and quality appraisal with AGREE II was conducted. Methods: We reviewed literature retrieved from PubMed, Web of Science, Ovid, ScienceDirect, Embase, China National Knowledge Infrastructure, WanFang Data, and guidelines websites. Search period from 1 January 2016 to 31 December 2021. The following keywords were used for searching: ‘atopic dermatitis’, ‘atopic eczema’, ‘eczema’, ‘guideline’ and ‘consensus’. The quality of the guidelines was assessed by two assessors using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument independently, and domain scores were considered of sufficient quality when > 60%. Guidelines recommendations were reviewed. Results: Nineteen guidelines were included in the study. Three guidelines were graded A level that recommended for use in practice. Eleven guidelines were graded B level that recommended for use in revision. The remaining five guidelines were rated C level not as recommended. The average score of six domains of AGREE II was 64.76%, 48.53%, 42.35%, 73.83%, 32.23% and 70.17%, respectively. The consistency test showed that ICC ranged from 0.497 (95%CI: 0.105, 0.705) to 0.970 (95%CI: 0.93, 0.987) in the results of two assessors’ tests of the guidelines. Conclusions: Most guidelines were recommended for use with revision in the study. No major changes in primary management of atopic dermatitis in children compared to previous evidence. New biologic agents and complementary alternative medicine were increasingly available, but evidence for the treatment of atopic dermatitis in children was still limited.