Cancer treatment has come a long way owing to the developments in various therapeutic modalities from discovery of various anticancer drugs, technological innovations in delivery to personalized treatments. Despite this, Head & Neck Cancer [HNC] is one such cancer that has eluded conventional treatments. To improves the quality of life and preserve vital organ function in patients focus is on therapeutic regimes which would reduce the toxicity. However, use of single approach has not been enough to completely eradicate this malignancy. Therefore, use of adjuvants and combinatorial approaches with molecules from natural compounds which have no or minimal side effects is a growing area of research. In this review we have discussed the potentiality of phytochemicals as adjuvants with chemo or radio therapy as well as nano-formulation as novel therapeutic strategy. We have also tried to delineate the associated challenges in clinical application of these therapies in HNC.