Respiratory outcomes
The validated Spanish version of the International Study of Asthma and
Allergies in Childhood (ISAAC) questionnaire was administered at the 48
month and 72 month visit. The following outcomes were assessed during
both visits, ever wheeze, current wheeze, and asthma. Ever wheeze was
defined as caregiver report of “Has your child ever had wheezing or
whistling in the chest at any time in the past?” and current wheeze was
defined based on response to “In the past 12 months, did your child
have wheezing or whistling in the chest?” To measure asthma, caregivers
responded to the following question, “Has your child ever had asthma in
their life?” Repeated wheeze was defined as caregivers reporting wheeze
during both 48 month and 72 month visits. Any ever wheeze was defined as
caregiver reporting ever wheeze at 48 or 72 months and any current
wheeze was identified as wheeze in the past 12 months at 48 or 72
months. Lastly, ever asthma was defined as asthma at either 48 or 72
months.