Respiratory outcomes
The validated Spanish version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was administered at the 48 month and 72 month visit. The following outcomes were assessed during both visits, ever wheeze, current wheeze, and asthma. Ever wheeze was defined as caregiver report of “Has your child ever had wheezing or whistling in the chest at any time in the past?” and current wheeze was defined based on response to “In the past 12 months, did your child have wheezing or whistling in the chest?” To measure asthma, caregivers responded to the following question, “Has your child ever had asthma in their life?” Repeated wheeze was defined as caregivers reporting wheeze during both 48 month and 72 month visits. Any ever wheeze was defined as caregiver reporting ever wheeze at 48 or 72 months and any current wheeze was identified as wheeze in the past 12 months at 48 or 72 months. Lastly, ever asthma was defined as asthma at either 48 or 72 months.