Side effects and toxicity
Acute GI symptoms were observed in 48(63.2%) patients (nausea, vomiting, loss of appetite, diarrhea) during the period of treatment: 26 (34.2%) cases of grade 1, 14 (18.4%) cases of grade 2, 8 (10.5%) cases of grade 3. There were 17 (22.3%) cases of patients with acute urinary symptoms: 9(11.8%) cases of grade 1, 6 (7.9%)cases of grade 2, 2 (2.6%)cases of grade 3. No grade 4 toxicity was observed. The most common hematological toxicity was neutropenia in 27(35.5%) followed by anemia in 10(13.2%) and thrombocytopenia in 4(5.2%).
A total of 15 (19.7%) patients have gastrointestinal late side effects: 7(9.2%) cases of grade 1, 5(6.6%) of grade 2, and 3 (3.9%) of grade 3. Additionally, a total of 20(26.3%) cases had urinary late toxicity, of which 11(14.5%) cases of grade 1, 5(6.6%) cases of grade 2, 4(5.2%) cases in grade 3. No grade 4 chronic toxicity was observed. Late side effects were mainly radiation cystitis 7(9.2%), radiation proctitis 5(6.6%), hydronephrosis 3(3.9%), intestinal obstruction 2(2.6%), and lower extremity edema 3(3.9%). Actuarial rate for G3 + G4 morbidity was 2.6%/3.9% for the GI, 3.9%/5.2% for the GU at 3/5 years, respectively.