Side effects and toxicity
Acute GI symptoms were observed in 48(63.2%) patients (nausea,
vomiting, loss of appetite, diarrhea) during the period of treatment: 26
(34.2%) cases of grade 1, 14 (18.4%) cases of grade 2, 8 (10.5%)
cases of grade 3. There were 17 (22.3%) cases of patients with acute
urinary symptoms: 9(11.8%) cases of grade 1, 6 (7.9%)cases of grade 2,
2 (2.6%)cases of grade 3. No grade 4 toxicity was observed. The most
common hematological toxicity was neutropenia in 27(35.5%) followed by
anemia in 10(13.2%) and thrombocytopenia in 4(5.2%).
A total of 15 (19.7%) patients have gastrointestinal late side effects:
7(9.2%) cases of grade 1, 5(6.6%) of grade 2, and 3 (3.9%) of grade
3. Additionally, a total of 20(26.3%) cases had urinary late toxicity,
of which 11(14.5%) cases of grade 1, 5(6.6%) cases of grade 2,
4(5.2%) cases in grade 3. No grade 4 chronic toxicity was observed.
Late side effects were mainly radiation cystitis 7(9.2%), radiation
proctitis 5(6.6%), hydronephrosis 3(3.9%), intestinal obstruction
2(2.6%), and lower extremity edema 3(3.9%). Actuarial rate for G3 + G4
morbidity was 2.6%/3.9% for the GI, 3.9%/5.2% for the GU at 3/5
years, respectively.