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Prevalence of sensitization to molecular food allergen components in Europe: a systematic review
  • +13
  • Daniil Lisik,
  • Athina Ioannidou,
  • Giulia Spolidoro,
  • Mohamed Ali,
  • Sungkutu Nyassi,
  • Yohannes Amera,
  • Graciela Rovner,
  • Ekaterina Khaleva,
  • Carina Venter,
  • Ronald van Ree,
  • Margitta Worm,
  • Berber Vlieg - Boerstra,
  • Aziz Sheikh,
  • Antonella Muraro,
  • Graham Roberts,
  • Bright Nwaru
Daniil Lisik
Goteborgs universitet Sahlgrenska Akademin

Corresponding Author:daniil.lisik@gmail.com

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Athina Ioannidou
Goteborgs universitet Sahlgrenska Akademin
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Giulia Spolidoro
Universita degli Studi di Milano Dipartimento di Scienze Cliniche e di Comunita
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Mohamed Ali
Goteborgs universitet Sahlgrenska Akademin
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Sungkutu Nyassi
Goteborgs universitet Sahlgrenska Akademin
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Yohannes Amera
Goteborgs universitet Sahlgrenska Akademin
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Graciela Rovner
Karolinska Institutet Institutionen for Neurobiologi vardvetenskap och samhalle
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Ekaterina Khaleva
University of Southampton Faculty of Medicine
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Carina Venter
University of Colorado Denver School of Medicine
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Ronald van Ree
Amsterdam Universitair Medische Centra
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Margitta Worm
Charite Universitatsmedizin Berlin Campus Berlin Buch
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Berber Vlieg - Boerstra
OLVG
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Aziz Sheikh
The University of Edinburgh Edinburgh Medical School
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Antonella Muraro
Universita degli Studi di Padova Dipartimento di Salute della Donna e del Bambino
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Graham Roberts
University of Southampton Faculty of Medicine
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Bright Nwaru
Goteborgs universitet Sahlgrenska Akademin
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Abstract

Recent reports indiciate that the prevelance of food allergy is increasing, but accurate estimates remain a challenge due to cross-reactivity and limited use of precise diagnostic methods. Component-resolved diagnostics (CRD), in which sensitization to individual molecular components of whole food allergen extracts is measured, is emerging as a promising tool for evaluation of sensitization profiles. In this systematic review, we summarized estimates of prevalence of sensitization to food allergen components in the general population in Europe. We searched seven databases with no restrictions on publication date or language. Two reviewers independently screened the literature and appraised the risk of bias in the included studies. From 4,776 de-duplicated records, five studies, with low to moderate overall risk of bias, were included and narratively synthesized. Forty-six components from 18 foods were investigated. Overall, the prevalence of sensitization was low, particularly for major allergens, and non-existent for 10 components (0% [95% CI 0-0.8]). The highest prevalence was seen for PR-10 proteins, such as Cor a 1.04 (13.6% [95% CI 10.9-16.9]). There were not enough studies to discern regional differences or perfom meta-analysis, highlighting the need for more population-representative studies in order to elucidate patterns of sensitization to food allergen components in Europe.