Abbreviations:
AHR, airway hyperresponsiveness; ANGPT, angiopoietin; ASM, airway smooth
muscle; BAL, brocho-alveolar lavage; βc, common receptor β subunit;
COPD, chronic obstructive pulmonary disease; DC, dendritic cell; EBUS,
endobronchial ultrasound; ECM, extracellular matrix; ECP, eosinophil
cationic protein; EDN, eosinophil derived neurotoxin; EGF, epidermal
growth factor; EMT, epithelial-mesenchymal transition; EPX, eosinophil
peroxidase; FcεRI, high affinity IgE; FeNO, fractional exhaled nitric
oxide; FDA, food and drug administration; FGF, fibroblast growth factor;
GINA, global initiative for asthma; GM-CSF, granulocyte-macrophage
colony-stimulating factor; HLM, human lung macrophage; HLMC, human lung
mast cell; HRCT, high-resolution computed tomography; IL, interleukins;
IL-5Rα, IL-5 receptor α; ILC, innate lymphoid cell; i.v., intravenously;
lfTSLP, long form TSLP; mAb, monoclonal antibody; MBP, major basic
protein; MMP, matrix metalloproteinase; NET, neutrophils extracellular
trap; NHR, nuclear magnetic resonance; NK cell, natural killer cell; NKT
cell, natural killer T cell; PDGF, platelet-derived growth factor;
PGD2, prostaglandin D2; RCTs, randomized
clinical trials; sfTSLP, short form TSLP; TGF-β, transforming growth
factor β; TSLP, thymic stromal lymphopoietin; T2-high, type 2-high;
T2-low, type 2-low; VDP, ventilation defect; VEGF, vascular endothelial
growth factors.