Antibiotic resistance is one of the greatest public health threats we face. Approximately 2 million infections and 23,000 deaths are a result of antibiotic-resistant bacteria in the United States every year.[1] It occurs when bacteria acquire immunity to antibiotic treatments. In response, pharmaceutical companies usually develop new or improved antibiotics. However, as consumers overuse and misuse these treatments, multidrug-resistant bacteria with no effective treatment(s) emerge. Unfortunately, the proliferation of such microbes threatens to return society to pre-antibiotic era health conditions. Fortunately, phage therapy offers a potential solution. Phage therapy uses bacteriophages, viruses that exclusively infect bacteria, to target and kill antibiotic-resistant microbes at infection sites. This paper explores phage therapy and the challenges faced by researchers in developing it. It concludes with a discussion on the importance of phage therapy in the future on a global level.