3. Roles of necroptosis in tissue fibrosis
Fibrosis represents excessive scar formation which occurs when the
normal wound healing response exceeds the normal tolerance of the tissue
in many organs. Both clinical manifestation and experimental study on
animal models indicated that fibrosis is a two-way and reversible
process (Weiskirchen et al. 2019). At present, the principles to reverse
fibrosis mainly include changeover the chronic tissue damage and
phlogosis, the demise of myofibroblasts and fibrolysis of excess matrix
scaffold. The in-depth comprehension of the molecular mechanisms of
various tissue fibrosis is the prerequisite for finding effective
biomarkers or and novel antifibrotic treatment options.