We investigate Schwarz lemma in the framework of bicomplex numbers, which are pairs of complex numbers making up a commutative ring with zero-divisors. The bicomplex is a generalization of complex which has closed relation with Frac- tal geometry, Minkowski Space-Time, Maxwell’s equations, Schrödinger equation and Gaussian pulse wave. In this paper, we first construct a type of bicomplex Möbius transformation and obtain some results : the mapping properties on bicom- plex spheres and bicomplex ball, preserving the inverse points with respect to the bicomplex sphere (0,1). Then we obtain the Poisson integral formula in bicom- plex setting, and by using the Poisson integral formula, we give the Schwarz lemma for bicomplex holomorphic functions in bicomplex setting. Finally, we shall give the Schwarz lemma and the Schwarz-Pick type lemma for holomorphic functions in bicomplex analysis. These results may give new energy for the development of quan- tum mechanics.