Conclusion
Laser ablation for the treatment of VaIN is effective and well-tolerated, requiring exclusion of malignant lesions of the lower anogenital tract. The MTLA method was individually carried out according to the comprehensive status including characteristics of lesions, high-risk factors and results of surveillance. It was recommended 3~5 number of laser ablation for the HSIL(VaIN2,3) and 2~3 number for the LSIL(VaIN1) patients to obtain a high pathological cure rate and HR-HPV clearance rate in our study. Larger areas of lesions and hysterectomy were independent risk factors for pathological persistence. It was harder for postmenopausal females to eliminate HR-HPV, and condemn use could protect patients from HR-HPV infection. Preventing vaginitis was important to reduce the complication incidence of laser ablation.