Strengths and Limitations
The most obvious strength of this study was newly proposed principle of
laser ablation for the old problem of the treatment for VaIN. Because of
the rarity of VaIN, small sample of patients remained the limitation of
the study. Though the pathological cure rate was high in the study, the
HPV clearance rate remained to be elevated. Also, the follow-up time was
not long enough to observe the relapse rate of the disease. Maybe a
large sample of randomized trial from multiple centers in the future
could provide more evidence for the efficacy of MTLA for the treatment
of VaIN.