Strengths and Limitations
The most obvious strength of this study was newly proposed principle of laser ablation for the old problem of the treatment for VaIN. Because of the rarity of VaIN, small sample of patients remained the limitation of the study. Though the pathological cure rate was high in the study, the HPV clearance rate remained to be elevated. Also, the follow-up time was not long enough to observe the relapse rate of the disease. Maybe a large sample of randomized trial from multiple centers in the future could provide more evidence for the efficacy of MTLA for the treatment of VaIN.