loading page

Relapsed Intracranial Non-Germinomatous Germ Cell Tumours: is it possible to achieve long-term survival?
  • +6
  • Mohamed Ahmed,
  • Stergios Zacharoulis,
  • Istvan Bodi,
  • Erika Pace,
  • Henry Mandeville,
  • Joanna Stone,
  • Tony Elias,
  • Bassel Zebian,
  • Fernando Carceller
Mohamed Ahmed
Royal Marsden NHS Foundation Trust
Author Profile
Stergios Zacharoulis
Columbia University
Author Profile
Istvan Bodi
King's College Hospital NHS Foundation Trust
Author Profile
Erika Pace
Royal Marsden Hospital NHS Trust
Author Profile
Henry Mandeville
Royal Marsden NHS Foundation Trust
Author Profile
Joanna Stone
Royal Marsden NHS Foundation Trust
Author Profile
Tony Elias
King's College Hospital NHS Foundation Trust
Author Profile
Bassel Zebian
King's College Hospital NHS Foundation Trust
Author Profile
Fernando Carceller
Royal Marsden Hospital Sutton

Corresponding Author:fernando.carceller@icr.ac.uk

Author Profile

Abstract

Non-germinomatous germ cell tumours of the central nervous system (CNS NG-GCT) have no standardized treatment at relapse and prognosis is dismal. Additionally, limited patient numbers preclude any clinical trials in this setting. Here we report the case of an adolescent with relapsed metastatic pineal yolk sac tumour treated with induction chemotherapy, high dose chemotherapy followed by autologous stem cell transplant and radiotherapy who is alive and progression-free 5 years after end of treatment. This experience illustrates the importance of tumour marker surveillance and that multimodal treatment can salvage children with relapsed CNS NG-GCT.