Epidemiological survey on oral allergy syndrome in patients with seasonal allergic rhinitis

Hypersensitivity reaction (HSR) to cisplatin can result in discontinuation of chemoradiotherapy in patients with head and neck squamous cell carcinoma (HNSCC). We present a nasopharyngeal carcinoma patient with cisplatin hypersensitivity successfully treated with cisplatin-desensitization. Desensitization therapy may be safe and beneficial in patients with HNSCC who develop HSR to cisplatin.

Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer that has no effective drugs. Herein, we report that comprehensive cancer mutation analysis revealed amplification of CD274 gene encoding PD-L1. Multiplex immunohistochemistry also clarified the presence of an immunosuppressive microenvironment via a PD-1/PD-L1 pathway in metastatic ITTC.