A female of 60 years old who suffered from 2-month intermittent upper abdominal pains, was adopted by the hospital. She once went through radical gastrectomy (Billrothâ…¡) oriented with gastric antral cancer. CE-CT and abdominal ultrasound displayed a primary tumor on the neck of pancreas. Pathological examination exhibited that the lesion is a Pancreatic Ductal Adenocarcinoma. According to the results of the imaging, the open approach radiofrequency ablation therapy was selected to be the treatment of the primary tumor. A local recurrent tumor was discovered in the follow-up CE-CT after 8 months with the performance of another open RFA. In spite of the evidence that RFA for the recurrence of other cancers like hepatocellular carcinoma might lengthen the survival of the patients, whether repeated RFA of local recurrence of pancreatic cancer is feasible is still unclear. The patient still enjoys her 9-year existence following the first RFA. It is promising that some cases still reveal the attainment of long-term survival based on repeated open RFA.