Although severe acute respiratory syndrome coronavirus 2 is primarily known for its significant and potentially fatal pulmonary manifestations, case reports and literature review have linked the infection to multiple organ systems, including hematological manifestations. Scattered among these reports are cases of lymphopenia and neutropenia as well as evidence of children presenting in hypercoagulable states related to COVID-19. We present a case describing a pediatric patient who presented with leukopenia, thrombocytopenia, and severe neutropenia: a unique combination based on the current literature.

Ewing sarcoma is an aggressive malignancy of bone and soft tissue that accounts for approximately 2% of cases of childhood cancer. It has been rarely reported as a secondary neoplasm. Data from the Childhood Cancer Survivor Study has evaluated secondary sarcomas in 5-year survivors of childhood cancer. We report two pediatric patients in northeast Pennsylvania, who developed secondary Ewing Sarcoma of the 9th rib within 5 years of primary childhood leukemia diagnoses.