Aim: We aim to investigate the endoscopic and CT scan findings of pediatric patients with Henoch-Schonlein purpura (HSP). Methods: The endoscopic and CT findings of the patients were observed. Endoscopy was carried out using the Olympus GIF XQ 230 electronic gastroscope. Laboratory tests were carried out to investigate the expression of potential markers in these patients. In total, 4 females and 2 males were included in this study, with the median age of 7.5 yrs. All the 6 patients underwent endoscopic examination. Results: One showed hyperemia and erosion in the gastric antrum, together with punctiform hyperemia in the gastric balloon and bile regurgitation. One showed erosion in the gastric fundus, body and angle, as well as hyperemia and edema in the descendant duodenum, together with massive erosion and ulcer. One showed hyperemia and erosion in the gastric antrum combined with ecchymosis in the descending part of stomach. One showed ecchymosis in the descendant duodenum, and a tendency of hemorrhage. One showed massive ecchymosis in the descendant part and horizontal part of the duodenum. The other one showed hyperemia in the descendant duodenum. Endoscopic findings of HSP consisted of mucous hyperemia and edema, together with local erosion and irregular ulcer. Some patients at the acute stage presented hemorrhagic spots and capillary hemorrhage, which usually involved the duodenum, gastric antrum and body. Conclusion: CT findings of the HSP were edema and thickening in the small intestinal wall, hydrops in the intestinal cavity and intestinal obstruction.