2.1 Search Strategy
The PubMed and Embase databases were used to systematically search for articles on PPK of OXC published before 31 October 2020 followed the principles of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The search terms used included “oxcarbazepine”, “oxcarbamazepine”, “ocbz”, “oxtellar”, or “trileptal” and “population pharmacokinetic”, “pharmacokinetic modeling”, “nonlinear mixed effect model”, “NONMEM”, “Pmetrics”, “WINNONMIX”, “ADAPT”, “P-PHARM”, “nlmixed”, “NLME”, “USC*PACK”, or “MONOLIX”. Besides, references of all included studies were searched.
All the relevant articles selected from the databases and reference lists were screened to evaluate their eligibility for inclusion according to the following criteria: target group of studies was human; OXC was the study drug; PPK analysis was conducted in the study; and the study was published in English. A study was excluded if it was a review or external evaluation article; the data presented overlapped with previous studies but with smaller sample sizes; or the PK parameters were incomplete. Two independent authors screened the title and abstracts as well as the full-text of each article to determine their eligibility. Discrepancies were resolved by a third senior investigator.