5. Conclusions
The PPK studies of OXC have been extensively reviewed. The PK of MHD has
a large difference between children and adults. Furthermore, children
have a larger variability in PK than adults. This review showed that to
optimise the dosing regimen of OXC, the weight, identity of
co-administered drugs, and renal function of patients should be
considered.
Acknowledgments:
The authors would like to sincerely thank Dr. Vincent Jullienfrom Service de Pharmacologie, Hôpital européen Georges Pompidou,
France; Yang Wang and Jing Peng from Department of
Pharmacy, Wuhan Children’s Hospital, China; Yunli Yu from
Department of Clinical Pharmacology, The Second Affiliated Hospital of
Soochow University, China for providing details about the research and
active discussions on the coding. We would like to thank Hai-ni
Wen MPharm from Shanghai Chest Hospital; and Ph.D. candidateXiao-qin Liu from Department of Pharmacy, Huashan Hospital, Fudan
University, China for their critical comments. We would also like to
thank Editage (www.editage.cn) for English language editing.
Funding :Not applicable