2.1 Search Strategy
The PubMed and Embase databases were used to systematically search for
articles on PPK of OXC published before 31 October 2020 followed the
principles of the Preferred Reporting Items for Systematic Reviews and
Meta-analyses (PRISMA) statement. The search terms used included
“oxcarbazepine”, “oxcarbamazepine”, “ocbz”, “oxtellar”, or
“trileptal” and
“population
pharmacokinetic”, “pharmacokinetic modeling”, “nonlinear mixed
effect model”, “NONMEM”, “Pmetrics”, “WINNONMIX”, “ADAPT”,
“P-PHARM”, “nlmixed”, “NLME”, “USC*PACK”, or “MONOLIX”.
Besides, references of all included studies were searched.
All
the relevant articles selected from the databases and reference lists
were screened to evaluate their eligibility for inclusion according to
the following criteria: target group of studies was human; OXC was the
study drug; PPK analysis was conducted in the study; and the study was
published in English. A study was excluded if it was a review or
external evaluation article; the data presented overlapped with previous
studies but with smaller sample sizes; or the PK parameters were
incomplete. Two independent authors screened the title and abstracts as
well as the full-text of each article to determine their eligibility.
Discrepancies were resolved by a third senior investigator.