3.1 Study Identification
A total of 155 articles were selected: 87 articles were selected from PubMed; 67 articles from the Embase database; and one article from the references of selected articles. After initial screening, 16 full-text studies were assessed for eligibility. One study was excluded because the final PK parameters were not presented [20], and two were excluded because of language [21, 22]. In addition, the study conducted by Sallas et al. [23] was excluded because the study data overlapped with that of Sugiyama et al. [24]. Finally, 12 articles were included in the study (Fig. 1 ).