5. Conclusions
The PPK studies of OXC have been extensively reviewed. The PK of MHD has a large difference between children and adults. Furthermore, children have a larger variability in PK than adults. This review showed that to optimise the dosing regimen of OXC, the weight, identity of co-administered drugs, and renal function of patients should be considered.
Acknowledgments:
The authors would like to sincerely thank Dr. Vincent Jullienfrom Service de Pharmacologie, Hôpital européen Georges Pompidou, France; Yang Wang and Jing Peng from Department of Pharmacy, Wuhan Children’s Hospital, China; Yunli Yu from Department of Clinical Pharmacology, The Second Affiliated Hospital of Soochow University, China for providing details about the research and active discussions on the coding. We would like to thank Hai-ni Wen MPharm from Shanghai Chest Hospital; and Ph.D. candidateXiao-qin Liu from Department of Pharmacy, Huashan Hospital, Fudan University, China for their critical comments. We would also like to thank Editage (www.editage.cn) for English language editing.
Funding :Not applicable