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880 nm NIR-triggered organic small molecular based nanoparticles for photothermal therapy of tumor
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  • Yunying Zhao,
  • Zheng He,
  • Qiang Zhang,
  • Jing Wang,
  • Wenying Jia,
  • Long Jin,
  • Linlin Zhao,
  • Yan Lu
Yunying Zhao
Tianjin University of Technology

Corresponding Author:1369115034@qq.com

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Zheng He
Tianjin University of Technology
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Qiang Zhang
Tianjin University of Technology
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Jing Wang
Tianjin University of Technology
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Wenying Jia
Tianjin University of Technology
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Long Jin
Tianjin University of Technology
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Linlin Zhao
Tianjin University of Technology
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Yan Lu
Tianjin University of Technology
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Abstract

Photothermal therapy (PTT) has received constant attention as efficient cancer therapy method due to locally selective treatment and not affected by tumor microenvironment. In this study, a novel 880 nm near-infrared (NIR) laser triggered photothermal agent (PTA), 3TT-IC-4Cl, was used for PTT of tumor in deep tissue. Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene gly-col-poly (β-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), TNPs exhibit excellent photothermal stability and photothermal conversion efficiency. Furthermore, the in vitro results showed TNPs display excel-lent biocompatibility and significant phototoxicity. These results suggest that 880 nm triggered TNPs has great potential as an effective PTAs for photothermal therapy of tumor in deep tissue.
18 Mar 2021Published in Nanomaterials volume 11 issue 3 on pages 773. 10.3390/nano11030773