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Predictive factors of acute respiratory events during initial induction chemotherapy in patients with advanced neuroblastoma
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  • Motohiro Matsui,
  • Atsushi Makimoto,
  • Nobuhiro Nishio,
  • Yoshiyuki Takahashi,
  • Mitsuyoshi Urashima,
  • Yuki Yuza
Motohiro Matsui
Tokyo Metropolitan Children’s Medical Center

Corresponding Author:motohiro612@yahoo.co.jp

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Atsushi Makimoto
Tokyo Metropolitan Children's Medical Center
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Nobuhiro Nishio
Nagoya University Graduate School of Medicine
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Yoshiyuki Takahashi
Nagoya University
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Mitsuyoshi Urashima
Jikei University School of Medicine
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Yuki Yuza
Tokyo Metropolitan Children's Medical Center
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Abstract

Background The present study aimed to identify the predictive factors of acute respiratory events (ARE), including severe hypoxia, during initial induction chemotherapy in patients with newly diagnosed advanced neuroblastoma. Method The medical records of 75 consecutive patients in whom stage III or IV neuroblastoma was newly diagnosed between January 2003 and December 2018 at two medical institutions were retrospectively reviewed. The outcome was ARE concomitant with severe hypoxia between the first and 14th days of initial induction chemotherapy. Severe hypoxia was defined as grade 3 or higher according to the Common Terminology Criteria for Adverse Events version 4 (CTCAE v4.0) or decreased oxygen saturation at rest (e.g., pulse oximeter < 88% or PaO2 ≤ 55 mmHg). Possible predictive factors on admission were first screened for using univariate analyses with a P value of 0.05, then models of the predictive power of the outcome were evaluated by generating receiver operating characteristic (ROC) curves. Results Eleven patients (14.7%) had the outcome, including three (4.0%) who required respiratory support in the intensive care unit. The area under the curve of the ROC for the predictive factors screened by univariate analyses were 0.84 (95% confidence interval (CI): 0.73-0.95) for lactate dehydrogenase (LDH) and 0.90 (95% CI: 0.82-0.98) for the disseminated intravascular coagulation (DIC) score. Conclusion The LDH value and DIC score on admission may be clinically useful predictors of ARE during initial induction chemotherapy in patients with advanced neuroblastoma.
May 2022Published in Cancer Reports volume 5 issue 5. 10.1002/cnr2.1499