ABSTRACT Berberis aristata DC. belonging to the family Berberidaceae, is a shrub used in the alternative medical systems that is native to Northen Himalaya region, Nepal, India and Pakisthan. It is commonly known as “Daruharidra and Chitra”. Berberis aristata DC. is used in Ayurvedic Medicinal system from the beginning of this System. It is widely used as a hepatoproctive, tonic, in urinary disorders, skin diseases, diaphoretic, diuretics and treatment of diarrhoea, Jaundice, Syphilis. Natural source of Berberine is Daruharidra which reduces the inflammation of hepatocytes in liver. The study was aimed to analyze its’ hepatoprotective effect on the basis of Modern scientific evidences and Classical Ayurveda references. Ayurvedic literature describes Daruharidra plant is mainly used in Kamala, Prameha, Kustha, Netra roga, Vrana.