Results
Method comparison
HEV IgG
The Mikrogen recom Well HEV IgG and the LIAISON Murex anti-HEV IgG
immunoassays were compared by analyzing 113 blood samples (either IgM,
IgG positive/borderline or IgG and IgM positive/borderline in the
Mikrogen test) and 49 IgG and IgM negative samples. Table 1 shows the
100% qualitative agreement between the results of both assays. The
sensitivity and the specificity is 100 % [95% CI, 0.96 to 1.00]
and 100 % [95% CI, 0.91 to 1.00], respectively. In addition, Table
1 demonstrates the qualitative agreement including the immunoblot
results. Again, the sensitivity is 100 % [95% CI, 0.96 to 1.00].
No specificity could be determined as no negative samples confirmed by
immunoblot were included.
Table 1 – Qualitative agreement of the recomWell/recomLine HEV
IgG and the LIAISON® Murex anti-HEV IgG immunoassays. The raw data can
be found in the supplement. In the recomWell HEV IgG test, a borderline
result means that the antibody concentration is in the range of 20 to 24
IU/ml.