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Vedolizumab therapy for pediatric steroid-refractory gastrointestinal acute graft-versus-host disease
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  • Kyohei Isshiki,
  • Takahiro Kamiya,
  • Akifumi Endo,
  • Kentaro Okamoto,
  • Tomoo Osumi,
  • Toshinao Kawai,
  • Katsuhiro Arai,
  • Daisuke Tomizawa,
  • Kazuo Ohtsuka,
  • Masakazu Nagahori,
  • Kosuke Imai,
  • Motohiro Kato,
  • HIrokazu Kanegane
Kyohei Isshiki
National Center for Child Health and Development
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Takahiro Kamiya
Tokyo Medical and Dental University Hospital
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Akifumi Endo
Tokyo Medical and Dental University Hospital
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Kentaro Okamoto
Tokyo Medical and Dental University Hospital
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Tomoo Osumi
National Center for Child Health and Development
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Toshinao Kawai
National Center for Child Health and Development
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Katsuhiro Arai
National Center for Child Health and Development
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Daisuke Tomizawa
National Center for Child Health and Development
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Kazuo Ohtsuka
Tokyo Medical and Dental University Hospital
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Masakazu Nagahori
Tokyo Medical and Dental University Hospital
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Kosuke Imai
Tokyo Medical and Dental University Hospital
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Motohiro Kato
National Center for Child Health and Development

Corresponding Author:katom-tky@g.ecc.u-tokyo.ac.jp

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HIrokazu Kanegane
Tokyo Medical and Dental University Hospital
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Abstract

Vedolizumab is an immunosuppressive drug that acts locally on the gastrointestinal tract, is mainly used for the treatment of inflammatory bowel disease, and has been reported to be effective against gastrointestinal acute graft-versus-host disease (GI-aGVHD) in adults. However, there is insufficient evidence for pediatric GI-aGVHD. We used vedolizumab in three cases of GI-aGVHD aged 1.5-4.4 years. It was significantly effective in two cases and all cases had no serious side effects. Vedolizumab might be effective and safe for pediatric GI-aGVHD refractory to other treatments. Future study awaits.