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Genetic predisposition to allergic rhinitis in relation to 11 psychiatric disorders
  • +11
  • Xiaowen Zhang,
  • Wenjing Liao,
  • Lijuan Song,
  • Junyang Xie,
  • Gui Chen,
  • Tianhao Liang,
  • Ang Li,
  • Chunyi Zhang,
  • Meiqian Xu,
  • Hao Li,
  • Jianlei Xie,
  • Pingchang Yang,
  • Deming Han,
  • Nanshan Zhong
Xiaowen Zhang
First Affiliated Hospital of Guangzhou Medical University

Corresponding Author:entxiaowen@163.com

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Wenjing Liao
First Affiliated Hospital of Guangzhou Medical University
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Lijuan Song
First Affiliated Hospital of Guangzhou Medical University
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Junyang Xie
First Affiliated Hospital of Guangzhou Medical University
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Gui Chen
First Affiliated Hospital of Guangzhou Medical University
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Tianhao Liang
First Affiliated Hospital of Guangzhou Medical University
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Ang Li
First Affiliated Hospital of Guangzhou Medical University
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Chunyi Zhang
First Affiliated Hospital of Guangzhou Medical University
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Meiqian Xu
First Affiliated Hospital of Guangzhou Medical University
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Hao Li
First Affiliated Hospital of Guangzhou Medical University
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Jianlei Xie
First Affiliated Hospital of Guangzhou Medical University
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Pingchang Yang
First Affiliated Hospital of Guangzhou Medical University
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Deming Han
First Affiliated Hospital of Guangzhou Medical University
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Nanshan Zhong
First Affiliated Hospital of Guangzhou Medical University
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Abstract

Background: Growing evidence from observational studies suggests a link between Allergic [rhinitis](https://www.sciencedirect.com/topics/neuroscience/rhinitis) (AR) and psychiatric disorders; whether these associations represent causal relationships remains uncertain. Methods: We performed bi-directional two-sample mendelian randomization (MR) using summary statistics from European genome-wide association studies to examine evidence of causality, specificity and direction of association of AR with 11 different psychiatric disorders or relevant traits. MR was conducted using the inverse-variance weighted method (IVW), MR-Egger and weighted median methods. Sensitivity analyses included the MR-Egger regression and MR pleiotropy residual sum and outlier test. Results: AR from 2 different GWAS data was positively associated with bipolar disorder (OR=1.649, 95% CI: 1.077-2.526; P=0.021; OR=1.599; 95%CI 1.058-2.417; P=0.026). AR was also associated with major depressive disorder (OR=1.539; 95%CI 1.007-2.353; P=0.047). There were no significant association between AR and other 9 psychiatric disorders. Bidirectional analyses showed that bipolar disorder is negatively associated with AR (OR=0.964; 95%CI: 0.936-0.993; P=0.015). There was no evidence for potential causal schizophrenia and effects of attention deficit/hyperactivity disorder on risk of AR by MR method, but, MR pleiotropy residual outlier test suggested that attention deficit/hyperactivity disorder is negatively associated with AR after outlier correction (OR=0.976, 95%CI: 0.958-0.995, P=0.012). Conclusions: This MR study indicated that AR was a causal risk factor for bipolar disorder and major depressive disorder, but not for other psychiatric disorders. Bipolar disorder and attention deficit/hyperactivity disorder may be a protective factor for AR. Further studies could be carried out to leverage these new found insight into better clinical and experimental research in AR and psychiatric disorders.