Key Points  Transoral resection for oral cavity and oropharyngeal cancer has become popular.  Transoral conventional interrupt knot tying suturing for oral/oropharyngeal defect often requires time.  Transoral barbed knotless continuous suture could reduce operation time with a comparable complication rate.  Knotless barbed suture provides appropriate tension and secure closure with multiple anchors.  Transoral barbed knotless suture is particularly advantageous in deep and narrow areas.