b. Fungal serology: anti-fungal specific IgG
Since fungi are ubiquitous, detecting anti-fungal specific IgG in the blood of individuals free of fungal disease is common. In contrast to specific IgE, IgG concentrations in healthy individuals vary greatly depending on the antigen, therefore reference values have to be established for each antigen (111). High concentrations of anti-fungal specific IgG may support ABPA/ABPM, HSP, infectious aspergillosis.
Unmet needs
The diversity and abundance of the fungal exposome stands in contrast with the unmet needs in knowledge and methods related to fungal effects on human health.