1. Little is known about the prevalence, specificity, patterns and temporal changes of sensitization to most airborne fungi.
We suggest tackling the fungal sensitization landscape, defined as the detectable IgE sensitization, its molecular targets and the putative clusters of relevant allergen families among a panel of fungal allergens. This panel should aim to fully represent the fungal exposome and its longitudinal evolution. Harnessing expertise in fungal ecology, fungal culture requirements, fungal allergen biochemistry including further characterization of allergens, cohort studies, fungus-induced immune responses, large-scale analysis of allergen investigations, and big data analysis will be necessary