REFERENCES
1. Echevarría ME, Fangusaro J, Goldman S. Pediatric central nervous
system germ cell tumors: a review. Oncologist.2008;13(6):690-699.
2. Gamis AS. Acute myeloid leukemia and Down syndrome evolution of
modern therapy–state of the art review. Pediatr Blood Cancer.2005;44(1):13-20.
3. Satgé D, Sommelet D, Geneix A, Nishi M, Malet P, Vekemans M. A tumor
profile in Down syndrome. Am J Med Genet. 1998;78(3):207-216.
4. Sadakata E, Yoshida K, Baba S, Fuku K, Matsuo T. A case of basal
ganglia germ cell tumor associated with Down’s syndrome. In: Nervous
System in Children; 2021.
5. Lehrnbecher T, Varwig D, Kaiser J, Reinhardt D, Klingebiel T,
Creutzig U. Infectious complications in pediatric acute myeloid
leukemia: analysis of the prospective multi-institutional clinical trial
AML-BFM 93. Leukemia. 2004;18(1):72-77.
6. Ullrich NJ, Robertson R, Kinnamon DD, et al. Moyamoya following
cranial irradiation for primary brain tumors in children.Neurology. 2007;68(12):932-938.
7. Hassler A, Bochennek K, Gilfert J, et al. Infectious Complications in
Children With Acute Myeloid Leukemia and Down Syndrome: Analysis of the
Prospective Multicenter Trial AML-BFM 2004. Pediatr Blood Cancer.2016;63(6):1070-1074.
8. Maeda Y, Yoshikawa K, Kajiwara K, et al. Intracranial yolk sac tumor
in a patient with Down syndrome. J Neurosurg Pediatr.2011;7(6):604-608.
9. Komiya K, Iwamoto H, Misugi K. A case of cerebellar tumor associated
with Down’s syndrome. Congenital Anomalies. 1975;15:212-213.
10. Nakato H, Kuwabara S, Maesako N, et al. [A case of Down’s syndrome
complicated by teratoma of the third ventricle of the brain (author’s
transl)]. No To Shinkei. 1982;34(2):145-150.
11. Yamasaki S, Hamasaki Y. A infant case of brain tumor associated with
Down’s syndrome (in Japanese). In. Vol 54. Arch Jpn Chir1985:305.
12. Fujita T, Yamada K, Saitoh H, Itoh S, Nakai O. Intracranial
germinoma and Down’s syndrome–case report. Neurol Med Chir
(Tokyo). 1992;32(3):163-165.
13. Oshita N, Yamashita K, Gotou K, Nagata I, Ueda H, Mitani T. [A
case of endodermal sinus tumor in the basal ganglia associated with
Down’s syndrome]. No Shinkei Geka. 1993;21(4):345-349.
14. Wada H, Kubo M, Wada T, et al. [A case report of a 6-year-old boy
with intracranial yolk sac tumor treated by VAB-6 regimen]. No
Shinkei Geka. 1995;23(1):65-68.
15. Nakashima T, Nishimura Y, Sakai N, Yamada H, Hara A. Germinoma in
cerebral hemisphere associated with Down syndrome. Childs Nerv
Syst. 1997;13(10):563-566.
16. Hokezu Y, Okada A, Kanehisa Y, Nagamatsu K, Matsunaga M. Down
syndrome associated with radiosensitive brain tumor. Shenkei
Naika. 1987;26(8):3.
17. Tanabe M, Mizushima M, Anno Y, et al. Intracranial germinoma with
Down’s syndrome: a case report and review of the literature. Surg
Neurol. 1997;47(1):28-31.
18. Matsumura N, Kurimoto M, Endo S, Fukuda O, Takaku A. Intracranial
germinoma associated with Down’s syndrome. Report of 2 cases.Pediatr Neurosurg. 1998;29(4):199-202.
19. Chik K, Li C, Shing MM, Leung T, Yuen PM. Intracranial germ cell
tumors in children with and without Down syndrome. J Pediatr
Hematol Oncol. 1999;21(2):149-151.
20. Tan HW, Ty A, Goh SG, Wong MC, Hong A, Chuah KL. Pineal yolk sac
tumour with a solid pattern: a case report in a Chinese adult man with
Down’s syndrome. J Clin Pathol. 2004;57(8):882-884.
21. Satoh S, Goto H, Izaki K, Sakuma H, Watanabe K. [Intracranial
germinoma associated with Down syndrome: case report and review of
literature]. No Shinkei Geka. 2012;40(2):137-143.
22. Sugimoto K, Ideguchi M, Sadahiro H, et al. Yolk sac tumor of the
bilateral basal ganglia in a patient with Down syndrome. Brain
Tumor Pathol. 2013;30(4):247-252.
23. Bakhtiar Y, Yonezawa H, Bohara M, et al. Posterior fossa immature
teratoma in an infant with trisomy 21: A case report and review of the
literature. Surg Neurol Int. 2012;3:100.
24. Robson CD, Price DL, Barnes PD, Taylor GA. Radiologic-pathologic
conference of Children’s Hospital Boston: pineal region mass in a
neonate. Pediatr Radiol. 1997;27(10):829-831.
25. Hashimoto T, Sasagawa I, Ishigooka M, et al. Down’s syndrome
associated with intracranial germinoma and testicular embryonal
carcinoma. Urol Int. 1995;55(2):120-122.
26. Nodomi S, Umeda K, Ueno H, et al. Efficacy of
Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in
a Child With Down Syndrome. J Pediatr Hematol Oncol.2017;39(1):e39-e42.
27. Endo S, Kobayashi H, Terasaka S, et al. Primary intracranial yolk
sac tumor in the posterior fossa: case report of a child with Down
syndrome. Clin Neurol Neurosurg. 2013;115(6):811-813.
28. Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL.
Brentuximab-vedotin maintenance following chemotherapy without
irradiation for primary intracranial embryonal carcinoma in down
syndrome. Childs Nerv Syst. 2018;34(4):777-780.
29. Miyake Y, Adachi JI, Suzuki T, Mishima K, Sasaki A, Nishikawa R.
Craniospinal Germinomas in Patient with Down Syndrome Successfully
Treated with Standard-Dose Chemotherapy and Craniospinal Irradiation:
Case Report and Literature Review. World Neurosurg.2017;108:995.e999-995.e915.
30. Tempaku A. Basal Ganglia Germinoma Associated with Down Syndrome in
a Female Patient. BAOJ Neurol. 2018;4:50.
31. Takada A, Ii N, Hirayama M, et al. Long-term follow-up of intensive
chemotherapy followed by reduced-dose and reduced-field irradiation for
intracranial germ cell tumor. J Neurosurg Pediatr.2018;23(3):317-324.
32. Dagri J, Torkildson J, Cheng J, et al. GC-08 CENTRAL NERVOUS SYSTEM
(CNS) GERM CELL TUMORS (GCT) AND DOWN SYNDROME: TREATMENT STRATEGIES AND
MORBIDITIES. In. Neuro Oncology (supplement)2012.
33. Kaatsch P, Rickert CH, Kühl J, Schüz J, Michaelis J.
Population-based epidemiologic data on brain tumors in German children.Cancer. 2001;92(12):3155-3164.
34. Keene D, Johnston D, Strother D, et al. Epidemiological survey of
central nervous system germ cell tumors in Canadian children. J
Neurooncol. 2007;82(3):289-295.
35. Ostrom QT, de Blank PM, Kruchko C, et al. Alex’s Lemonade Stand
Foundation Infant and Childhood Primary Brain and Central Nervous System
Tumors Diagnosed in the United States in 2007-2011. Neuro Oncol.2015;16 Suppl 10:x1-x36.
36. Zhou D, Zhang Y, Liu H, Luo S, Luo L, Dai K. Epidemiology of nervous
system tumors in children: a survey of 1,485 cases in Beijing Tiantan
Hospital from 2001 to 2005. Pediatr Neurosurg. 2008;44(2):97-103.
37. Shibui S. Report of brain tumor registry of Japan (2001–2004).Neurologia medico-chirurgica. 2014;54(suppl. 1).
38. Poynter JN, Fonstad R, Tolar J, Spector LG, Ross JA. Incidence of
intracranial germ cell tumors by race in the United States, 1992-2010.J Neurooncol. 2014;120(2):381-388.
39. Kakkar A, Biswas A, Kalyani N, et al. Intracranial germ cell tumors:
a multi-institutional experience from three tertiary care centers in
India. Childs Nerv Syst. 2016;32(11):2173-2180.
40. Sano K. Pathogenesis of intracranial germ cell tumors reconsidered.J Neurosurg. 1999;90(2):258-264.
41. Wang M, Zhou P, Zhang S, et al. Clinical features, radiologic
findings, and treatment of pediatric germ cell tumors involving the
basal ganglia and thalamus: a retrospective series of 15 cases at a
single center. Childs Nerv Syst. 2018;34(3):423-430.
42. Crawford JR, Santi MR, Vezina G, et al. CNS germ cell tumor (CNSGCT)
of childhood: presentation and delayed diagnosis. Neurology.2007;68(20):1668-1673.
43. Kyritsis AP. Management of primary intracranial germ cell tumors.J Neurooncol. 2010;96(2):143-149.
44. Bartels U, Onar-Thomas A, Patel SK, et al. Phase II Trial of
Response-Based Radiation Therapy for Patients with Localized Germinoma:
A Children’s Oncology Group Study. Neuro Oncol. 2021.
45. Calaminus G, Bison B, Faure-Conter C, et al. GCT-76. 24Gy WHOLE
VENTRICULAR RADIOTHERAPY ALONE IS SUFFICIENT FOR DISEASE CONTROL IN
LOCALISED GERMINOMA IN CR AFTER INITIAL CHEMOTHERAPY – EARLY RESULTS OF
THE SIOP CNS GCT II STUDY. Neuro-Oncology. 2020;22(Suppl
3):iii343-iii344.
46. Calaminus G, Frappaz D, Kortmann RD, et al. Outcome of patients with
intracranial non-germinomatous germ cell tumors-lessons from the
SIOP-CNS-GCT-96 trial. Neuro Oncol. 2017;19(12):1661-1672.
47. Goldman S, Bouffet E, Fisher PG, et al. Phase II Trial Assessing the
Ability of Neoadjuvant Chemotherapy With or Without Second-Look Surgery
to Eliminate Measurable Disease for Nongerminomatous Germ Cell Tumors: A
Children’s Oncology Group Study. J Clin Oncol.2015;33(22):2464-2471.
48. Huang X, Zhang R, Zhou LF. Diagnosis and treatment of intracranial
immature teratoma. Pediatr Neurosurg. 2009;45(5):354-360.
49. Calaminus G, Kortmann R, Worch J, et al. SIOP CNS GCT 96: final
report of outcome of a prospective, multinational nonrandomized trial
for children and adults with intracranial germinoma, comparing
craniospinal irradiation alone with chemotherapy followed by focal
primary site irradiation for patients with localized disease.Neuro Oncol. 2013;15(6):788-796.
50. Goldstein NA, Armfield DR, Kingsley LA, Borland LM, Allen GC, Post
JC. Postoperative complications after tonsillectomy and adenoidectomy in
children with Down syndrome. Arch Otolaryngol Head Neck Surg.1998;124(2):171-176.
Statements and Declarations : The authors do not have any
conflicts of interest to disclose. No funding was used to support this
work. The authors have no financial interests to disclose. All authors
contributed to the study conception and design. Material preparation,
data collection and analysis was performed by Micah K. Harris and
Mohamed S. Abdelbaki. The first draft of the manuscript was written by
Micah K. Harris, and all authors commented on previous versions of the
manuscript. All authors read and approved the final manuscript.
Data Sharing: The data that support the findings of this study
are available from the corresponding author upon reasonable request.