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Clinical Scope and Healthcare Utilization in Childhood Interstitial Lung Disease at a Tertiary Center
  • +5
  • Lisa Young,
  • Lance Feld,
  • Laura Voss,
  • Zeyu Nancy Li,
  • Jessica Rice,
  • Maureen B Josephson ,
  • Yun Li,
  • Sharon McGrath-Morrow
Lisa Young
The Children's Hospital of Philadelphia

Corresponding Author:youngl5@chop.edu

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Lance Feld
The Children's Hospital of Philadelphia
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Laura Voss
The Children's Hospital of Philadelphia
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Zeyu Nancy Li
The Children's Hospital of Philadelphia
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Jessica Rice
The Children's Hospital of Philadelphia
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Maureen B Josephson
The Children's Hospital of Philadelphia
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Yun Li
The Children's Hospital of Philadelphia
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Sharon McGrath-Morrow
The Children's Hospital of Philadelphia
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Abstract

Childhood interstitial lung disease (chILD) is a heterogeneous group of diffuse lung diseases (DLD) that can be challenging to diagnose. With relative rarity of individual entities, data are limited on disease prevalence, care patterns, and healthcare utilization. The objective of this study was to evaluate chILD prevalence and review diagnostic and clinical care patterns at our center. A single-center, retrospective cohort study was conducted of patients receiving care at the Children’s Hospital of Philadelphia (CHOP) between January 1, 2019, and December 31, 2021. Through query of selected ICD-10 billing codes relevant for chILD/DLD, a total of 306 patients were identified receiving care during this period. Respiratory symptom onset was documented to have developed before two years of age for 40% of cases. The most common diagnostic categories included those with oncologic disease (21.2%), bronchiolitis obliterans (10.1%), and connective tissue disease (9.5%). Genetic testing was performed in 49% of cases, while 36% underwent lung biopsy. Hospitalization at CHOP had occurred for 80.4% of patients, with 45.1% ever hospitalized in an intensive care unit. One-third of children had required chronic supplemental oxygen. Seven (2.3%) patients died during this three-year period. Collectively, these data demonstrate the scope of chILD and extent of health care utilization at a large volume tertiary care center. This approach to cohort identification and EMR-driven data collection in chILD provides new opportunities for cohort analysis and will inform the feasibility of future studies.
26 Mar 2023Submitted to Pediatric Pulmonology
26 Mar 2023Submission Checks Completed
26 Mar 2023Assigned to Editor
26 Mar 2023Review(s) Completed, Editorial Evaluation Pending
28 Mar 2023Reviewer(s) Assigned
29 May 2023Editorial Decision: Revise Minor
19 Jun 20231st Revision Received
19 Jun 2023Submission Checks Completed
19 Jun 2023Assigned to Editor
19 Jun 2023Review(s) Completed, Editorial Evaluation Pending
19 Jun 2023Reviewer(s) Assigned
03 Jul 2023Editorial Decision: Accept