Generalized eruptive histiocytoma is a rare disease. GEH belongs to the family of non-Langerhans-cell histiocytoses. An 18-year-old man presented with disseminated papules on his trunk. Pathological studies confirmed the diagnosis of GEH. We administered systemic PUVA treatment and a significant response was observed after 20 sessions.

We hereby, present the first case of Acute generalized exanthematous pustulosis (AGEP) following treatment with remdesivir in a patient with COVID-19 without hydroxychloroquine use which serves as a reminder for considering remdesivir as a possible causative agent when dealing with AGEP presentation in COVID patients.