Familial aggregation of stillbirth
Among stillbirth cases, we identified 2,498 (26.6%) probands with
high-risk pedigrees (n=390), showing evidence for excess stillbirth
familial aggregation (FSIR ≥2.00 and P-value <0.05) in the
UPDB population (Table 1 ). Among high-risk pedigrees, the FSIR
values ranged from 2.00 to 7.54 (Figure S2 ), indicating that
the aggregation of stillbirth in the pedigrees is 2–8 times greater
than what we would expect in the UPDB population by chance. A
representative high-risk pedigree (pedigree #3 in Table 1 )
displayed in Figure 1 shows 10 stillbirth cases that descended
from a common founder.