References
1. Flenady V, Wojcieszek AM, Middleton P, Ellwood E, Erwich JJ, Coory M, Khong TY, Silver RM, Smith GCS, Boyle FM, Lawn JE, Blencowe H, Leisher SH, Gross MM, Horey D, Farrales L, Bloomfield F, McCowan L, Brown SJ, Joseph KS, Zeitlin J, Reinebrant HE, Cacciatore J, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell AEP, Storey C, Sadler L, Petersen S, Frøen JF, Goldenberg RL, for The Lancet Ending Preventable Stillbirths study group, The Lancet Stillbirths In High-Income Countries Investigator Group. Stillbirths: recall to action in high-income countries. The Lancet 2016;387(10019):691–702.
2. Stillbirth Collaborative Research Network Writing Group. Causes of death among stillbirths. JAMA 2011;306(22):2459–68.
3. Reddy UM, Page GP, Saade GR, Silver RM, Vanessa R Thorsten VR, Parker CB, Pinar H, Willinger M, Stoll BJ, Heim-Hall J, Varner MW, Goldenberg RL, Bukowski R, Wapner RJ, Drews-Botsch CD, O’Brien BM, Dudley DJ, Levy B, NICHD Stillbirth Collaborative Research Network. Karyotype versus microarray testing for genetic abnormalities after stillbirth. N Engl J Med 2012;367(23):2185–93.
4. Stanley KE, Giordano J, Thorsten V, Buchovecky C, Thomas A, Ganapathi M, Liao J, Dharmadhikari AV, Revah‑Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker CB, Goldenberg R, Saade GR, Dudley DJ, Pinar H, Hogue C, Reddy UM, Silver RM, Aggarwal V, Allen AS, Wapner RJ, Goldstein DB. Causal Genetic Variants in Stillbirth. N Engl J Med 2020;383(12):1107–16.
5. Bhattacharya S, Amalraj Raja E, Ruiz Mirazo E, Campbell DM, Lee AJ, Norman JE, Bhattacharya S. Inherited predisposition to spontaneous preterm delivery. Obstet Gynecol 2010;115(6):1125–33.
6. Wu W, Witherspoon DJ, Fraser A, Witherspoon DJ, Fraser A, Clark EAS, Rogers A, Stoddard GJ, Manuck TA, Chen K, Esplin SM, Smith KR, Varner MW, Jordy LB. The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth. Hum Genet 2015;134(7):803–8.
7. Porter TF, Fraser AM, Hunter CY, Ward RH, Varner MW. The risk of preterm birth across generations. Obstet Gynecol 1997;90(1):63–7.
8. Svensson AC, Pawitan Y, Cnattingius S, Reilly M, Lichtenstein P. Familial aggregation of small-for-gestational-age births: the importance of fetal genetic effects. Am J Obstet Gynecol 2006;194(2):475–9.
9. Wikström A-K, Svensson T, Kieler H, Cnattingius S. Recurrence of placental dysfunction disorders across generations. Am J Obstet Gynecol 2011;205(5):454.e1-8.
10. Ananth CV, Jablonski K, Myatt L, James M. Roberts JM, Tita ATN, Leveno KJ, Reddy UM, Varner MW, Thorp JM, Mercer BM, Peaceman, Ramin SM, Carpenter MW, Samuels P, Sciscione A, Tolosa JE, Saade G, Sorokin Y, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. Am J Perinatol 2019;36(6):624–31.
11. Chesley LC, Annitto JE, Cosgrove RA. The familial factor in toxemia of pregnancy. Obstet Gynecol 1968;32(3):303–11.
12. Nilsson E, Salonen Ros H, Cnattingius S, Lichtenstein P. The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study. BJOG Int J Obstet Gynaecol 2004;111(3):200–6.
13. Esplin MS, Fausett MB, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 2001;344(12):867–72.
14. Woolner AMF, Raja EA, Bhattacharya S, Danielian P, Bhattacharya S. Inherited predisposition to stillbirth: an intergenerational analysis of 26,788 mother-daughter pairs. Am J Obstet Gynecol 2019;220(4):393.e1-393.e7.
15. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol 1993;68(4):495–532.
16. Utah Population Database. Utah Population Database - Huntsman Cancer Institute | University of Utah. (2021, July 8). https://uofuhealth.utah.edu/huntsman/utah-population-database/.
17. Silver RM, Branch DW, Goldenberg R, Iams JD, Klebanoff MA. Nomenclature for pregnancy outcomes: time for a change. Obstet Gynecol 2011;118(6):1402–8.
18. National Center for Health Statistics (U.S.), Dundon ML, Gay GA, George JL, editors. The 1978 revision of the U.S. standard certificates. Hyattsville, Md. : Washington, D.C: U.S. Dept. of Health and Human Services, Public Health Service, National Center for Health Statistics ; For sale by the Supt. of Docs., U.S. G.P.O; 1983.
19. Guide to Completing the Facility Worksheets for the Certificate of Live Birth and Report of Fetal Death (2003 revision). [Internet]. 2006;Available from: http://www.cdc.gov/nchs/data/dvs/GuidetoCompleteFacilityWks.pdf
20. DuVall SL, Fraser AM, Rowe K, Thomas A, Mineau GP. Evaluation of record linkage between a large healthcare provider and the Utah Population Database. J Am Med Inform Assoc JAMIA 2012;19(e1):e54-59.
21. Reddy UM, Ko C-W, Willinger M. Maternal age and the risk of stillbirth throughout pregnancy in the United States. Am J Obstet Gynecol 2006;195(3):764–70.
22. Fretts RC, Schmittdiel J, McLean FH, Usher RH, Goldman MB. Increased maternal age and the risk of fetal death. N Engl J Med 1995;333(15):953–7.
23. Kerber RA. Method for calculating risk associated with family history of a disease. Genet Epidemiol 1995;12(3):291–301.
24. Lange K, Sinsheimer JS. Calculation of genetic identity coefficients. Ann Hum Genet 1992;56(4):339–46.
25. Coon H, Darlington T, Pimentel R, Smith KR, Huff CD, Hu H, Jerominski L, Hansen J, Klein M, Callor WB, Byrd J, Bakian A, Crowell SE, McMahon WM, Rajamanickam V, Camp NJ, McGlade E, Yurgelun-Todd D, Grey T, Gray D. Genetic risk factors in two Utah pedigrees at high risk for suicide. Transl Psychiatry 2013;3:e325.
26. Wapner RJ, Lewis D. Genetics and metabolic causes of stillbirth. Semin Perinatol 2002;26(1):70–4.
27. Miskovic S, Culic V, Konjevoda P, Pavelic J. Positive reproductive family history for spontaneous abortion: predictor for recurrent miscarriage in young couples. Eur J Obstet Gynecol Reprod Biol 2012;161(2):182–6.
28. Pouta A, Järvelin M-R, Hemminki E, Sovio U, Hartikainen A-L. Mothers and daughters: intergenerational patterns of reproduction. Eur J Public Health 2005;15(2):195–9.
29. Woolner AMF, Raja EA, Bhattacharya S, Danielian P, Bhattacharya S. Inherited susceptibility to miscarriage: a nested case-control study of 31,565 women from an intergenerational cohort. Am J Obstet Gynecol 2020;222(2):168.e1-168.e8.
30. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007;8(4):253–62.
31. Wilkins-Haug L. Genetic innovations and our understanding of stillbirth. Hum Genet 2020;139(9):1161–72.
32. Adams MM, Wilson HG, Casto DL, Berg CJ, McDermott JM, Gaudino JA, McCarthy BJ. Constructing reproductive histories by linking vital records. Am J Epidemiol 1997;145(4):339–48.
33. McLellan T, Jorde LB, Skolnick MH. Genetic distances between the Utah Mormons and related populations. Am J Hum Genet 1984;36(4):836–57.
Table 1 . The top 10 high-risk pedigrees with statistically significant evidence for familial aggregation of stillbirth.