Methods
Using standard definitions, PPLs
categorized by type including maternal and fetal vascular, inflammatory
and immune/idiopathic lesions. Using single-nucleotide polymorphism
array, CNVs of at least 500kb detected. CNVs classified into two groups:
normal, defined as no CNVs>500kb or benign CNVs, and
abnormal, defined as pathogenic or variants of unknown clinical
significance.