AUTHOREA
Log in
Sign Up
Browse Preprints
LOG IN
SIGN UP
Please note
: Importing new articles from Word documents is currently unavailable. We are working on fixing this issue soon and apologize for any inconvenience.
Sylvia Cheng
Public Documents
2
Whole genome transcriptome analysis in a case of a neonatal soft tissue sarcoma with...
Arielle Locke
and 7 more
January 27, 2023
Soft tissue sarcomas in neonates are rare and heterogeneous tumors. We report an aggressive neonatal undifferentiated round cell sarcoma with a YWHAE:NUTM2B fusion. The tumor was identified antenatally and the neonate underwent surgical resection at four days of age. Whole-genome and transcriptome sequencing of tumour and germline was undertaken to provide molecular characterization and elucidate possible novel therapies. In addition to molecular characterization of a YWHAE:NUTM2B fusion, RNA expression outliers were described. Targeted therapy was not pursued due to rapid clinical decline. Understanding the genomic profile of rare tumors remains important in the development of novel therapeutic strategies.
Comment on: Primary Cutaneous Lymphomas in Children and Adolescents Primary cutaneous...
Paul D'Alessandro
and 6 more
February 07, 2022
Comment on: Primary Cutaneous Lymphomas in Children and Adolescents