3is the β ‑pinene-derived pyridyl carboxylic acid substituted quinoline oligoamide foldamer at N-terminal. The computational results show that the free-energy difference is 4.77 kcalmol-1 between P-3a and M-3a . The R chirality of terminal atom still induces the P helix and S chirality of terminal atom still induces the M helix(Supporting information S6).