A 53-year-old lady presented with an 18-month history of an erythematous pruritic rash 3 weeks following the COVID Moderna vaccination booster. Following this she developed a tan like colour to her skin with evidence of tiny white crystals over the superficial layer in keeping with a diagnosis of uraemic frost.

Cutaneous squamous cell carcinoma (cSCC) is the second most common non melanoma skin cancer after Basal cell carcinoma, characterised by the malignant proliferation of epidermal keratinocytes. We report a case of an inoperable cSCC of the scalp extending into the sagittal sinus, now responding well to the monoclonal antibody Cemiplimab.