Conclusion
Elevated levels of BRD4 may be used to predict the enlargement and
fibrosis of the left atrium, postoperative recurrence of AF after
ablation, and reduced LVEF in patients with NVAF. Moreover, the
postoperative recurrence rate after ablation of AF was significantly
positively correlated with LAAPD and the low voltage regions of the left
atrium, and negatively correlated with LVEF and LAA-PEV. Inhibition of
BRD4 expression significantly improved the degree of left atrial
fibrosis in rats with AF, and reduced the incidence and duration of AF.
BRD4 may be involved in atrial fibrosis and remodeling through the
TGF-β1/Smad signaling pathway, thus participating in the occurrence and
maintenance of AF.