Figure 4: Secondary structure prediction and homology model of IRX4 homeodomain A) Secondary structure of IRX4 as predicted by PSIPRED. B) 3D structure of IRX4 homeodomain as modelled by SWISS-MODEL (figure generated using UCSF Chimera). The three conserved helices of the homeodomain as highlighted in pink. The conservation map of the IRX4-DNA Binding Domain was calculated using the ConSurf server. Ribbons are displayed based on conservation scores. C) The model of IRX4 dimer bound to DNA. The ribbons displayed in rainbow colours are IRX4-DNA Binding Domain dimers bound to DNA (coloured from blue to red representing N- to C-terminus of protein).