Chemical reactions are often carried out under mixing, especially at an industrial scale. Mixing aims to homogenize the concentrations and temperatures of reactants over a whole reactor, and therefore often requires a 3D flow and sometimes a 2D flow. This mixing-driven-chemistry ignores or does not have to consider the effects of flow/mixing on reaction kinetics and/or selectivity because flow/mixing is likely not strong enough to significantly drive molecules from their equilibrium conformations to non-equilibrium ones. This article proposes flow-driven-chemistry which aims at manipulating the dynamics and structural order of molecules (conformation, alignment, diffusion and collision) through a strong 1D flow in order to tune the reaction kinetics and/selectivity. It describes the scientific and technical bases of flow-driven chemistry as well as its scientific and technical challenges. It provides the state of the art of the understanding related to flow-driven chemistry and perspectives for future developments.