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Anti-nonspecific adsorption segments-assisted self-driven surface imprinted fibers for efficient protein separation
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  • Zuoting Yang,
  • Ting Wang,
  • Yabin Wang,
  • Qiuyu Zhang,
  • Baoliang Zhang
Zuoting Yang
Northwestern Polytechnical University

Corresponding Author:278308034@qq.com

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Ting Wang
Northwestern Polytechnical University
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Yabin Wang
Northwestern Polytechnical University
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Qiuyu Zhang
Northwestern Polytechnical University
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Baoliang Zhang
Northwestern Polytechnical University
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Abstract

At present, the development of high-performance protein imprinted materials is still a research hotspot in the field of protein imprinting. Herein, anti-protein adsorption segment (CBMA)-assisted self-driven BSA surface imprinted fibers MTCFs@SIP@CBMA with high recognition selectivity are pioneered using the strategies of combining magnetic nanomaterial surface imprinting technique with amino-Michael addition. The special structure of the carrier MTCFs endows MTCFs@SIP@CBMA with magnetic performance and self-driven adsorption performance, which simplifies the separation process while improving the adsorption capacity and accelerating the adsorption rate. The adsorption capacity for BSA reached 395.26 mg/g within 30 min. The introduction of CBMA segments on the surface after imprinting by amino-Michael addition makes its polymer chain length and position controllable. Under the strongest anti-nonspecific adsorption effect, MTCFs@SIP@CBMA exhibit excellent specific identification to BSA from mixed proteins. Additionally, MTCFs@SIP@CBMA show considerable reusability. Therefore, MTCFs@SIP@CBMA are expected to be applied in efficient separation of proteins in biological samples.
30 Nov 2021Submitted to AIChE Journal
05 Dec 2021Submission Checks Completed
05 Dec 2021Assigned to Editor
08 Dec 2021Reviewer(s) Assigned
24 Mar 2022Editorial Decision: Revise Minor
02 Apr 20221st Revision Received
03 Apr 2022Submission Checks Completed
03 Apr 2022Assigned to Editor
05 Apr 2022Reviewer(s) Assigned
27 Apr 2022Editorial Decision: Revise Minor
06 May 20222nd Revision Received
11 May 2022Submission Checks Completed
11 May 2022Assigned to Editor
24 May 2022Editorial Decision: Accept
Oct 2022Published in AIChE Journal volume 68 issue 10. 10.1002/aic.17802