Panel A Full (original) dataset Panel A Full (original) dataset Panel B After exclusion of certain factors Panel B After exclusion of certain factors
Risk factors p-value Odds ratio (OR) p-value Odds ratio (OR)
Age ≥ 65 years < 0.0001 3.13 [95% 1.91-5.14] < 0.0001 2.82 [95% 1.78-4.47]
Female gender 0.001 2.34 [95% 1.41-3.87] 0.0073 1.86 [95% 1.18-2.94]
BMI ≥ 30 kg/m2 0.1263 1.49 [95% 0.89-2.48] - -
Ischemic cardiomyopathy and/or hypertension 0.0019 2.30 [95% 1.36-3.90] 0.002 2.13 [95% 1.32-3.45]
Arrhythmia 0.0399 2.11 [95% 1.04-4.32] 0.1409 1.60 [95% 0.85-3.03]
Thyroid disturbances 0.3354 0.76 [95% 0.44-1.32] 0.4565 0.82 [95% 0.49-1.38]
Liver failure 0.9957 2.052e+16 - -
Diabetes 0.6610 1.12 [95% 0.68-1.85] - -
Neurological disease 0 0 - -
Potassium ≤ 3.5 mmol/L 0.0223 2.08 [95% 1.10-3.89] 0.0186 2.01 [95% 1.12-3.59]
Calcium < 2.15 mmol/L 0.8508 1.07 [95% 0.51-2.25] 0.1955 0.65 [95% 0.34-1.25]
CRP > 5 mg/L 0.0025 2.66 [95% 1.41-4.99] - -
eGFR ≤ 30 ml/min 0.9926 6.1009e-9 - -
Drugs from CredibleMeds List 1 1 drug compared to 0 drug
2 drugs compared to 0 drug
2 drugs compared to 1 drug
3 drugs compared to 0 drug
3 drugs compared to 1 drug
3 drugs compared to 2 drugs
4 drugs compared to 0 drug
4 drugs compared to 1 drug
4 drugs compared to 2 drugs
4 drugs compared to 3 drugs
0.6113 0.3647 0.5437 0.0141 0.0193 0.0643 0.9990 0.9990 0.9990 0.9990 1.16 [95% 0.65-2.09] 1.45 [95% 0.65-3.20] 1.24 [95% 0.62-2.50] 4.45 [95% 1.35-14.66] 3.82 [95% 1.24-11.76] 3.08 [95% 0.94-10.14] 202368716 173842620 140020824 45470298 0.4526 0.8389 0.4092 0.0098 0.0023 0.0180 0.9975 0.9975 0.9975 0.9977 0.82 [95% 0.48-1.38] 1.08 [95% 0.53-2.20] 1.32 [95% 0.68-2.53] 4.20 [95% 1.41-12.46] 5.13 [95% 1.80-14.67] 3.90 [95% 1.26-12.03] 28877919 35325006 26820887 6882448.9
Drugs from CredibleMeds List 2 1 drug compared to 0 drug
2 drugs compared to 0 drug
2 drugs compared to 1 drug
3 drugs compared to 0 drug
3 drugs compared to 1 drug
3 drugs compared to 2 drugs
0.2052 <0.0001 <0.0001 0.9960 0.9961 0.9955 0.69 [95% 0.39-1.22] 5.50 [95% 2.31-13.10] 7.93 [95% 3.22-19.52] 1.2548e-7 1.8068e-7 2.2794e-8 0.0270 0.0001 <0.0001 0.9906 0.9910 0.9898 0.55 [95% 0.33-0.93] 4.22 [95% 2.02-8.81] 7.64 [95% 3.47-16.81] 1.2351e-7 2.2379e-7 2.9274e-8
Drugs from CredibleMeds List 3 1 drug compared to 0 drug
2 drugs compared to 0 drug
2 drugs compared to 1 drug
3 drugs compared to 0 drug
3 drugs compared to 1 drug
3 drugs compared to 2 drugs
4 drugs compared to 0 drug
4 drugs compared to 1 drug
4 drugs compared to 2 drugs
4 drugs compared to 3 drugs
6 drugs compared to 0 drug
6 drugs compared to 1 drug
6 drugs compared to 2 drugs
6 drugs compared to 3 drugs
6 drugs compared to 4 drugs
0.6860 0.4414 0.2027 0.8340 0.5355 0.6133 0.6551 0.4218 0.8992 0.7873 0.9980 0.9980 0.9979 0.9979 0.9979 0.86 [95% 0.42-1.77] 1.32 [95% 0.65-2.69] 1.53 [95% 0.79-2.95] 1.09 [95% 0.48-2.45] 1.26 [95% 0.60-2.65] 0.83 [95% 0.39-1.74] 1.25 [95% 0.47-3.28] 1.44 [95% 0.59-3.55] 0.94 [95% 0.38-2.33] 1.14 [95% 0.43-3.02] 1.7753e-8 2.0581e-8 1.3436e-8 1.6279e-8 1.4244e-8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -