Drug-drug interaction warning analysis
Upon analysis of DDI warnings, we identified a variety of drug
combinations. It is important to mention, however, that the DDI
combinations listed in table A.4 in the supplementary appendix only
refer to those that actually triggered and were not filtered. All
warnings that triggered were severe and most were overridden, whereas
those that were filtered were mostly moderate in nature. The combination
of oral amiodarone and IV haloperidol contributed to 13% of all alerts
and occurred in only one patient, resulting in QTc prolongation. Another
drug combination was IV ondansetron in addition to IV haloperidol, which
triggered in two patients and resulted in QTc prolongation 83% of the
time. IV ondansetron formed the majority of the remaining DDI warnings
in combination with sotalol, methadone, levofloxacin, ciprofloxacin,
propofol, promethazine, trazodone, azithromycin, and arsenic trioxide.