Figure 4. Tshr mutations in Western European common vole populations. Manhattan-type plots (-log10(p )) for the sequenced Tshr region for (A) geographical distance, (D) latitude, (G) longitude, (J) altitude and (M) predicted critical photoperiod (pCPP). Grey bars indicate Benjamini-Hochberg adjusted p-values, black bars indicate R2-values. SNPs that meet the threshold for significant correlations (p < 0.05) cross the red dashed line. Pairwise difference in SNP frequency for two representative mutations (SNP-158 and SNP126) related to (B,C) pairwise geographical distance, (E,F) pairwise latitudinal difference, (H,I) pairwise longitudinal difference, (K,L) pairwise altitudinal difference and (N,O) pairwise difference in pCPP. Significant correlations are indicated by linear regression lines. All statistic results of linear models for SNP frequency related to environmental proxies can be found in Table S6.