REFERENCES
1. Wu X, Yin C, Ma J, et al. Polyoxypregnanes as safe, potent, and
specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in
cancer chemotherapy in vitro and in vivo. Acta Pharm Sin B
2021;11:1885-1902.
2. Mallina H, Elumalai R, S FDP, et al. Computational validation of
ABCB1 gene polymorphism and its effect on tacrolimus dose
concentration/levels in renal transplant individuals of South India.
Comput Biol Med 2021;139:104971.
3. Azam F, Khan M, Khaliq T, et al. Influence of ABCB1 gene polymorphism
on concentration to dose ratio and adverse effects of tacrolimus in
Pakistani liver transplant recipients. Pak J Med Sci 2021;37:689-694.
4. Sallustio BC, Noll BD, Hu R, et al. Tacrolimus dose, blood
concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics,
are associated with allograft tacrolimus concentrations in renal
transplant recipients. Br J Clin Pharmacol 2021;87:3901-3909.
5. Qin XL, Chen X, Zhong GP, et al. Effect of Tacrolimus on the
pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra
sphenanthera extract) and the potential roles of CYP3A and P-gp.
Phytomedicine 2014;21:766-72.
6. Li X, Zhao K, Ma N, et al. Association of ABCB1 promoter methylation
with aspirin exposure, platelet function, and clinical outcomes in
Chinese intracranial artery stenosis patients. Eur J Clin Pharmacol
2017;73:1261-1269.
7. Correa S, Binato R, Du Rocher B, et al. ABCB1 regulation through
LRPPRC is influenced by the methylation status of the GC -100 box in its
promoter. Epigenetics 2014;9:1172-83.
8. Chen Z, Cheng X, Zhang L, et al. The impact of IL-10 and CYP3A5 gene
polymorphisms on dose-adjusted trough blood tacrolimus concentrations in
early post-renal transplant recipients. Pharmacol Rep 2021;73:1418-1426.
9. Peng W, Lin Y, Zhang H, et al. Effect of ABCB1 3435C>T
Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult
Renal Transplant Recipients: A Systematic Review and Meta-analysis. Clin
Ther 2020;42:2049-2065.
10. Kronfol MM, Jahr FM, Dozmorov MG, et al. DNA methylation and histone
acetylation changes to cytochrome P450 2E1 regulation in normal aging
and impact on rates of drug metabolism in the liver. Geroscience
2020;42:819-832.
11. Chequin A, Costa LE, de Campos FF, et al. Antitumoral activity of
liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in
vivo. Chem Biol Interact 2021;349:109641.
12. He H, Wang P, Li SG, et al. [Effects of pargyline on histone
methylation in promoter and enhancer regions and transcription of
CYP3A4/3A7]. Yao Xue Xue Bao 2017;52:91-8.
13. Lkhagvadorj K, Zeng Z, Meyer KF, et al. Postnatal Smoke Exposure
Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke
Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation.
Int J Mol Sci 2020;22.
14. Wang X, Wei L, Yang J, et al. DNA methylation determines the
regulation of pregnane X receptor on CYP3A4 expression. Clin Exp
Pharmacol Physiol 2021;48:250-259.
15. Onda K, Suzuki R, Tanaka S, et al. Decitabine, a DNA
methyltransferase inhibitor, reduces P-glycoprotein mRNA and protein
expressions and increases drug sensitivity in drug-resistant MOLT4 and
Jurkat cell lines. Anticancer Res 2012;32:4439-44.
16. Li S, Zhang Y, Ho SH, et al. Combination of tumour-infarction
therapy and chemotherapy via the co-delivery of doxorubicin and thrombin
encapsulated in tumour-targeted nanoparticles. Nat Biomed Eng
2020;4:732-742.
17. Liu H, Yang ZK, Li Y, et al. ABCB1 variants confer susceptibility to
primary open-angle glaucoma and predict individual differences to
latanoprost treatment. Biomed Pharmacother 2016;80:115-120.
18. Jonaitis P, Jonaitis L, Kupcinskas J. Role of Genetic Polymorphisms
of Cytochrome P450 2C19 in Pantoprazole Metabolism and
Pantoprazole-based Helicobacter pylori Eradication Regimens. Curr Drug
Metab 2020;21:830-837.
19. Habano W, Kawamura K, Iizuka N, et al. Analysis of DNA methylation
landscape reveals the roles of DNA methylation in the regulation of drug
metabolizing enzymes. Clin Epigenetics 2015;7:105.
20. Habano W, Gamo T, Sugai T, et al. CYP1B1, but not CYP1A1, is
downregulated by promoter methylation in colorectal cancers. Int J Oncol
2009;34:1085-91.
21. Nakajima M, Iwanari M, Yokoi T. Effects of histone deacetylation and
DNA methylation on the constitutive and TCDD-inducible expressions of
the human CYP1 family in MCF-7 and HeLa cells. Toxicol Lett
2003;144:247-56.
22. Ye L, Xu Y, Wang L, et al. Downregulation of CYP2E1 is associated
with poor prognosis and tumor progression of gliomas. Cancer Med 2021.
23. Luo R, Ge C, Xiao X, et al. Identification of genetic variations
associated with drug resistance in non-small cell lung cancer patients
undergoing systemic treatment. Brief Bioinform 2021;22.
24. Ohmura H, Ito M, Uchino K, et al. Methylation of drug
resistance-related genes in chemotherapy-sensitive Epstein-Barr
virus-associated gastric cancer. FEBS Open Bio 2020;10:147-157.
25. Xu L, Wang Y. Combined influence of ABCB1 genetic polymorphism and
DNA methylation on aspirin resistance in Chinese ischemic stroke
patients. Acta Neurol Belg 2021.
26. Wang J, Huang L, Gao P, et al. Diltiazem on tacrolimus exposure and
dose sparing in Chinese pediatric primary nephrotic syndrome: impact of
CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms. Eur J Clin Pharmacol
2021;77:71-77.
27. Vaclavikova R, Klajic J, Brynychova V, et al. Development of
highresolution melting analysis for ABCB1 promoter methylation: Clinical
consequences in breast and ovarian carcinoma. Oncol Rep 2019;42:763-774.
28. Wu P, Ni X, Wang M, et al. Polymorphisms in CYP3A5*3 and MDR1, and
haplotype modulate response to plasma levels of tacrolimus in Chinese
renal transplant patients. Ann Transplant 2011;16:54-60.
29. Yildirim E, Sahin G, Kaltus Z, et al. Effect of CYP3A5 and ABCB1
Gene Polymorphisms on Tacrolimus Blood Concentration in Renal Transplant
Recipients. Clin Lab 2019;65.
30. Wu LX, Zhao HB, Wen CJ, et al. Combined Influence of Genetic
Polymorphism and DNA Methylation on ABCB1 Expression and Function in
Healthy Chinese Males. Eur J Drug Metab Pharmacokinet 2017;42:627-634.
31. Wu LX, Wen CJ, Li Y, et al. Interindividual epigenetic variation in
ABCB1 promoter and its relationship with ABCB1 expression and function
in healthy Chinese subjects. Br J Clin Pharmacol 2015;80:1109-21.
32. Yang J, Zhou JS, Zhao YX, et al. ABCB1 hypomethylation is associated
with decreased antiplatelet effects of clopidogrel in Chinese ischemic
stroke patients. Pharmazie 2015;70:97-102.