Figure 2.Contrast-enhanced computed tomography scan showing subglottic
tumor with an enhanced pre laryngeal node.
Direct laryngoscopy and biopsy was performed under general anesthesia.
The histopathology findings were suggestive for neuroendocrine
carcinoma. Microscopic histopathology analysis showed a tumor consist of
small size neoplastic cells with acidophilic cytoplasm, coarse chromatin
pattern with areas of necrosis and a high mitotic rate (more than
10/mm2).Immunohistochemistry was positive for creatine kinase 7,
synaptophysin, chromogranin, Cluster of differentiation (CD) 56, and
ki67(Figure 3). The Ki-67 index was 45%. These findings were consistent
with the diagnosis of small cell NEC.